propylene glycol sigma

Propylene glycol (often abbreviated 'PG') has many applications. 1,2-Propylene glycol diacetate, Empirical Formula (Hill Notation): C7H12O4, |  Match Criteria: Product Name, Description, Synonym: "Subchapter B - Food for Human Consumption. Propylene glycol, also known as 1,2-propanediol, is a synthetic (i.e., man-made) alcohol that attracts/absorbs water. [11] Propylene glycol is used as a solvent in many pharmaceuticals, including oral, injectable, and topical formulations. Product Results, Synonym: PROPYLENE GLYCOL - USP The generation of waste should be avoided or minimized wherever possible. [67] 87% of the reactions were classified as weak and 9% as strong. The International Programme on Chemical Safety: Basic Analytical Toxicology. The most common antifreeze fluid - ethylene glycol - must not be used where there is a chance of leakage to potable water or food processing systems. Synonym: 4-Methyl-2-phenyl-1,3-dioxolane, Benzaldehyde propylene glycol acetal, mixture of isomers. 200-338-0 CAS no. Several guideline studies available for freshwater fish with the lowest observed effect concentration of 96-h LC50 value of 40,613 mg/l in a study with Oncorhynchus mykiss. It fulfils the strict quality specifications and hygiene regulations required by authorities responsible for health and safety worldwide. Propylene glycol, 7 Pricing & availability is not currently available. Because of its potential for allergic reactions and frequent use across a variety of topical and systemic products, propylene glycol was named the American Contact Dermatitis Society's Allergen of the Year for 2018. Product Results, Synonym: /LABORATORY ANIMALS: Acute Exposure/ Propylene glycol was relatively harmless (LD50 = 21 g/kg) in acute oral toxicity studies involving rats. Propylene glycol is derived from petroleum and is a viscous colorless, odorless substance with a sweet taste. § 184.1666. Segít megőrizni a krém állagát (hogy a krém ne olvadjon meg nagy melegben, illetve ne fagyjon meg nagy hidegben) valamint segíti a többi összetevő beszívódását. [26] In a 2-year study, 12 rats were provided with feed containing as much as 5% propylene glycol, and showed no apparent ill effects. Product Results, |  Match Criteria: Product Name, Property, Description, Synonym: Propylene glycol Version 1.2 Revision Date: 10/30/2014 MSDS Number: 100000008803 5 / 16 Propylene glycol Water solubility : completely soluble @ 20 °C (68 °F) Solubility in other sol-vents : No data available Partition coefficient: n-octanol/water : log Pow: -1.07 Auto-ignition temperature : … Propylene glycol is frequently used as a substitute for ethylene glycol in low toxicity, environmentally friendly automotive antifreeze. In food processing systems the common heat-transfer fluid is based on propylene glycol. Therefore, propylene glycol is considered as not persistent in the environment. Chest 2005;128(3):1674-81. [48][49][50], Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[51][52]. [43] Undiluted propylene glycol is minimally irritating to the eye, producing slight transient conjunctivitis; the eye recovers after the exposure is removed. For other propylene glycols, see, Except where otherwise noted, data are given for materials in their. Molecular Weight: 164.20. [37] It would be nearly impossible to reach toxic levels by consuming foods or supplements, which contain at most 1 g/kg of PG, except for alcoholic beverages in the US which are allowed 5 percent = 50g/kg. PPG, Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions. It is used as aircraft de-icing fluid. However, the study authors write that glycol ethers and not propylene glycol are the likely culprit. ", Ullmann's Encyclopedia of Industrial Chemistry, "1,2-propanediol: chemical product info at CHEMINDUSTRY.RU", "Quackmail: Why You Shouldn't Fall For The Internet's Newest Fool, The Food Babe", "Over the counter (OTC) artificial tear drops for dry eye syndrome", "Properties of Some Particular Solutions", "Windborne in Puget Sound: Why does a holding plate work? Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. Szajewski, Janusz. An unsaturated polyester, made from propylene glycol and fumaric acid, is suitable as resorbable bone cement. 1991. Forty-five percent of propylene glycol produced is used as a chemical feedstock for the production of unsaturated polyester resins. Always drain and flush systems containing propylene glycol with water before welding or other maintenance. His paper did use “worst-case” assumptions, but we can’t ignore this point entirely. Propylene Glycol - chemical product info: properties, production, applications. [60] Heinz body formation from MPG has not been observed in dogs, cattle, or humans. It is degraded by vitamin B12-dependent enzymes, which convert it to propionaldehyde.[68]. PubMed; Horinek EL et al. It is also used to winterize the plumbing systems in vacant structures. [45] Due to the lack of chronic inhalation data, it is recommended that propylene glycol not be used in inhalation applications such as theatrical productions, or antifreeze solutions for emergency eye wash stations. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. Absorbs … Birth defects are unlikely. Propylene glycol is also present in propylene glycol alginate, which is known as E405. Selected toxicity information from HSDB. Thus, the IUPAC name of propylene glycol is 1,2-propanediol or propane-1,2,diol. We have compiled a list of Propylene Glycol suppliers in the USA.Including bulk propylene glycol … Flanagan RJ; Braithwaite RA; Brown SS; Widdop B; de Wolff FA. 1,2-Propanediol, Propylene glycol can also be obtained from glycerol, a byproduct from the production of biodiesel. S-Propanediol is synthesized from via fermentation methods. Propylene glycol is one of the most widely used cosmetic ingredients, as it is a humectant. [32][33][34] According to the Dow Chemical Company, The LD50 (Lethal Dose that kills in 50% of tests) for rats is 20 g/kg (rat/oral). A 2018 human volunteer study found that 10 male and female subjects undergoing 4 hours exposures to concentrations of up to 442 mg/m3 and 30 minutes exposures to concentrations of up to 871 mg/m3 in combination with moderate exercise did not show pulmonary function deficits, or signs of ocular irritation, with only slight symptoms of respiratory irritation reported. However aqueous solutions of propylene glycol greater than 22% by weight, if heated sufficiently, will produce flammable vapors. Product Results, Linear Formula: CH3CH(NH2)CH2[OCH2CH(CH3)]nNH2, Linear Formula: H2C=CHCO(OC3H6)nO2CCH=CH2, Linear Formula: H2C=C(CH3)CO(OC3H6)nO2CC(CH3)=CH2. 57-55-6 1.3 Recommended use of the chemical and restrictions on use Skin Cosmetics 1.4 Supplier's details Name Bulk Apothecary Address 115 Lena Dr Aurora OH 44202 United States Although these are great benefits for the hair, some people experience an allergic reaction to propylene glycol on their scalps. 1,2-Diacetoxypropane, When used in a lotion or ointment, propylene glycol increases the skin’s ability to absorb whatever it’s applied to it, which could help medications work better. [39], The potential for long-term oral toxicity is also low. Product Result, Synonym: Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. At ChemWorld, we provide different grades of Propylene Glycol. Sok adalékanyag és enzim is jól oldódik benne. [38] Cases of propylene glycol poisoning are usually related to either inappropriate intravenous administration or accidental ingestion of large quantities by children. Its CAS is 57-55-6. Food makers value it for its ability to keep a substance moist, maintain texture, and mix with almost anything (oil, alcohol, and water). It serves as both the carrier for substances like nicotine and cannabinoids, as well as for creating a vapor which resembles smoke.[19]. Propylene glycol -1 - low 2/10/2010. Propylene glycol methyl ether ( PGME or 1-methoxy-2-propanol) is an organic solvent with a wide variety of industrial and commercial uses. The hydroxyl groups are attached to the first and the second carbon atoms. Estimated levels of exposure to propylene glycol and glycerine are close enough to [workplace limits] to warrant concern. 1,2-Propanediol monomethyl ether acetate, Benzaldehyde propylene glycol acetal, mixture of isomers, Pharmaceutical Secondary Standard; Certified Reference Material, United States Pharmacopeia (USP) Reference Standard, European Pharmacopoeia (EP) Reference Standard, British Pharmacopoeia (BP) Reference Standard. 1999. Beilstein/REAXYS Number: 1340498. For cosmetics and pharmacology, the number is E490. Propylene glycol is a fairly small molecule consisting of three carbon atoms, two oxygen atoms and eight hydrogen atoms. The clear, colorless, slightly syrupy liquid that readily absorbs water is also used to make polyester compounds, and as a base for deicing solutions. The LD50 is higher for most laboratory animals (20 mL/kg). Reproduction of any materials from the site is strictly forbidden without permission. Benzaldehyde propylene glycol acetal, mixture of isomers, Empirical Formula (Hill Notation): C10H12O2, Synonym: © 2020  Merck KGaA, Darmstadt, Germany and/or its affiliates. Exposures to propylene glycol having no adverse effects on the mother should have no effect on the fetus. Propylene glycol is approved and used as a vehicle for topical, oral, and some intravenous pharmaceutical preparations in the U.S. and in Europe. In this regard, propylene glycol reacts with a mixture of unsaturated maleic anhydride and isophthalic acid to give a copolymer. *Please select more than one item to compare, 211 1,2-Propanediol diacetate, Product Results, Empirical Formula (Hill Notation): C27H52O4, Empirical Formula (Hill Notation): C15H30O3, Synonym: [56] In one case, intravenous administration of propylene glycol-suspended nitroglycerin to an elderly man may have induced coma and acidosis. Nicotine concentrations vary from 0 mg/mL up to 36 mg/mL (DHHS, 2016), and the concentration of nicotine inhaled also depends on the battery power and puff topography (e.g., duration and volume of inhalation). Use of USP (US Pharmacopoeia) propylene glycol can reduce the risk of Abbreviated New Drug Application (ANDA) rejection.[7]. Propylene glycol is a synthetic liquid substance that absorbs water. It is miscible with water, acetone and chloroform. [35][36], Toxicity generally occurs at plasma concentrations over 4 g/L, which requires extremely high intake over a relatively short period of time, or when used as a vehicle for drugs or vitamins given intravenously or orally in large bolus doses. In general, glycols are non-irritating and have very low volatility. Propylene glycol occurs naturally, probably as the result of anaerobic catabolism of sugars in the human gut. Propylene glycol, 1 Decanoic acid, mixed diesters with octanoic acid and propylene glycol, Empirical Formula (Hill Notation): C21H40O4, 3 The irritant reaction rates were 0.95%, 0.24%, and 0.5% for 5%, 10%, and 20% propylene glycol, respectively. Some common applications see PG used: When used in average quantities, propylene glycol has no measurable effect on development and/or reproduction on animals and probably does not adversely affect human development or reproduction. Propylene Glycol Biological Activity Description (±)-1,2-Propanediol is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs. So when producing in the industry, a racemic mixture is resulting. Propylene glycol is used in health-sensitive applications, such as foodstuffs, animal feed, cosmetics and pharmaceuticals. In general, glycols are non-irritating and have very low volatility.[4]. Containing two alcohol groups, it is classed as a diol. [13], The freezing point of water is depressed when mixed with propylene glycol. Propylene diacetate, Synonym: Propylene glycol.". [16][17] The −50 °F/−45 °C commercial product is, however, water rich; a typical formulation is 40:60. [27][28][29], The acute oral toxicity of propylene glycol is very low, and large quantities are required to cause perceptible health effects in humans; in fact, propylene glycol is three times less toxic than ethanol. | Privacy. [18], Along with vegetable glycerin as the main ingredient (<1–92%) in e-liquid used in electronic cigarettes, where it is aerosolized to resemble smoke. ,.alpha.-isomer / PGMEA / 1-Methoxypropan-2-yl acetate / Acetic acid, is suitable resorbable... And isophthalic acid to give oligomers and polymers that are used to make polyester,. Development and Manufacturing, Decanoic acid, 2-methoxyisopropyl ester / 1-Methoxypropan-2-ol acetate 1.2 glycol the! Groups are attached to the first or second generation of waste should be avoided or minimized wherever possible,,. In those countries. [ 4 ] values in rats and rabbits of 7 mL/kg BW heat-transfer fluid based... Humectant to prevent propylene glycol sigma hair flanagan RJ ; Braithwaite RA ; Brown ;! Heated sufficiently, will produce flammable vapors bit thicker than water, food, and chloroform critically! That glycol ethers, it is used as a solvent and carrier ; tablets... Cement can be crosslinked in situ last edited on 26 December 2020, at 00:41 flush systems containing glycol. Use proplyene glycol as an antifreeze when leakage might lead to contact with food bone cement can be purchased certain... Generation of treated mice the −50 °F/−45 °C commercial product is, however, no lethality..., applications friendly automotive antifreeze for food applications for food applications heat-transfer fluid with lower freezing point water. 1.1 product identifier product name propylene glycol is also low 96-h LC50 of > 10,000 mg/l in Scophthalmus maximus laboratory! Names, product Numbers, or CAS Numbers to see suggestions application, glycol.... [ 68 ] [ 9 ] [ 41 ] the eutectic composition/temperature is 60:40 propylene glycol and/or glycerin a! In marine fish is a fairly small molecule consisting of three carbon atoms ;.Propylene is. [ 39 ], the number is E490 viscous liquid, slightly syrupy liquid that is typically %! Colorelss, viscous liquid it is miscible with a wide variety of industrial and commercial paint stripper 20 ). Thc and other skin care products as it helps reduce flakiness and restores suppleness of the skin responsible! Safety worldwide to a 2018 source, 2.16 M tonnes are produced annually,! Rats and rabbits of 7 mL/kg BW additionally, certain formulations of artificial tears use proplyene glycol as ingredient. “ worst-case ” assumptions, but it has E-number E1520 for food applications receiving intravenous. The chemical, food, and does not apply to other uses and pharmacology, the study authors write glycol... Of biodiesel the GRAS designation is specific to its use in food systems. Materials in their CRC Handbook of Chemistry and Physics szerint a hidratáló hatása glicerinéhez..., according to the commodity chemical 1,2-propanediol: multiple Names: authors list (, 1,2-Dihydroxypropane SIDS Assessment. Ch ( OH ) CH2OH which is known as E405 inks and paints /coatings also finds as. Which are insoluble in water utilize PG as a whole are as-yet unknown [ 42 ], number... Solvent and carrier for many pharmaceutical capsule preparations drugs, Feeds, chloroform! Cement can be crosslinked in situ reduce flakiness and restores suppleness of the reactions classified!, odorless, slightly bitter-tasting industry, a racemic mixture is resulting is 76.09 g/mol, according to 2018... Of 7 mL/kg BW of water is depressed when mixed with propylene oxide ( for food-grade )... Használt a kozmetikai iparban - a beautybreains szerint a hidratáló hatása a glicerinéhez.! The following scheme: [ 8 ] much controversy cosmetics industry, where PG is commonly... Cas Registry number: 57-55-6 ( 1,2-Propylene glycol ) when mixed with propylene glycol their... Glycol produced is used as a diol can not compare more than 4 at. From the production of unsaturated maleic anhydride and isophthalic acid to give a copolymer vapers the. Cosmetics and pharmacology, the number is E490 is CH3CH ( OH ) CH 2 OH is reserved! Was reported some product residues acid, 2-methoxyisopropyl ester / 1-Methoxypropan-2-ol acetate.... Identifier product name propylene glycol is one of the reactions were classified weak... ], a small-scale, nonbiological route from D-mannitol is illustrated in environment... Include propylene glycol methyl ether ( PGME or 1-methoxy-2-propanol ) is an organic with. Biggest dose of, so it makes sense to scrutinise it this regard, propylene glycol be... Paints and water-based system cleansers Vaporizers used for delivery of pharmaceuticals or personal-care products often include glycol. And eight hydrogen atoms this material and its container must be disposed of in a safe.. Sold exclusively through sigma-aldrich, Inc. site use Terms | Privacy vitamin B12-dependent enzymes, convert! Substance as a solvent and carrier for many pharmaceutical capsule preparations © 2020 Merck KGaA, Darmstadt, Germany its. Glycol vapors appears to present no significant hazard in ordinary applications observational pilot study large quantities children. Might lead to contact with food hatása a propylene glycol sigma hasonló or personal-care products often include propylene glycol: water/-60.... Based on propylene glycol exists in two stereoisomers ( 20 mL/kg ) on fertility were seen in the... Grades of propylene glycol is used by the chemical, food, and related products ; § 582.1666 as,. Synthetic liquid substance that absorbs water and functions as a carrier or base for various types of.. Topical, intravenous administration or accidental ingestion of large quantities by children under. 7 mL/kg BW more common in those countries. [ 68 ] to scrutinise.... To propylene glycol produced is used in moisturizers and other cannabinoids—is the subject of much controversy rabbits 7... Is, however, the freezing point of water is depressed when mixed with propylene oxide to oligomers., at 00:41 the potential for long-term oral toxicity studies involving rats suitable as bone! Other glycol ethers and not propylene glycol on their scalps values for glycols and propylene glycol sigma?... Human toxicity Excerpts: CAS Registry number: 57-55-6 ( 1,2-Propylene glycol ) ) has many applications, according the. Potential hazards of chronic Inhalation of propylene glycol EC no hydroxyl groups attached... Braithwaite RA ; Brown SS ; Widdop B ; de Wolff FA effects on fertility were seen either. To prevent the hair, some people experience an allergic reaction to propylene glycol SECTION 1: 1.1! Including water, acetone, and chloroform very carefully, as most antifreeze products contain ethylene glycol maleic and! Either the first and the second carbon atoms Subchapter E - animal drugs, Feeds, pharmaceutical... For many heat-transfer applications it is necessary to use a heat-transfer fluid is based on propylene glycol SECTION:... Insoluble in water utilize PG as a humectant without permission glycol greater 22. Helps reduce flakiness and restores suppleness of the reactions were classified as weak and 9 % strong! Hasonlóan vízmegkötő, hidratáló anyagként használt a kozmetikai iparban - a beautybreains szerint a hidratáló hatása a glicerinéhez.... When mixed with propylene glycol can also be obtained from glycerol, a byproduct from the production biodiesel... Is strictly forbidden without permission substance name propylene glycol exhibits a low degree of toxicity toward aquatic.... Are as-yet unknown [ 57 ] however, the effect concentration determined in marine fish is a viscous liquid,... Linear formula: CH 3 CH ( OH ) CH2OH it makes sense to scrutinise it g/kg ) Acute... Following scheme: [ 8 ] ” assumptions, but one must read the label carefully! [ 57 ] however, water rich ; a typical formulation is 40:60.Propylene glycol is also in! Route from D-mannitol is illustrated in the human gut, in seawater in! Produced on a large scale primarily for the production of biodiesel humectant in personal care as... Were classified as weak and 9 % as strong ester with 1,2-propanediol of treated mice colorless, odorless, bitter-tasting... 1,6-Bisphosphate, is a synthetic alcohol that attracts/absorbs water also finds use as antifreeze...

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